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How EKTERLY Works

Actor portrayal

EKTERLY halts the attack

EKTERLY works by blocking plasma kallikrein, which is a protein that plays a key role in swelling in hereditary angioedema (HAE) attacks.

  • How EKTERLY® (sebetralstat) works

    In people with HAE, plasma kallikrein becomes overactive.

  • How EKTERLY® (sebetralstat) works

    When plasma kallikrein is overactive, excessive fluid leaks through the walls of blood vessels and into body tissues.

  • How EKTERLY® (sebetralstat) works

    Increased fluid buildup leads to the swelling that people with HAE experience during
    an attack.

  • How EKTERLY® (sebetralstat) works

    EKTERLY works to stop attacks from getting worse by blocking plasma kallikrein.

EKTERLY begins
blocking plasma
kallikrein
in as little as
15 minutes.*

*Based on 600-mg data from a phase 2 study.

Ask your doctor if EKTERLY
could be right for you.

Start the conversation

INDICATION AND IMPORTANT SAFETY INFORMATION

WHAT IS EKTERLY® (sebetralstat)?

EKTERLY is a prescription medicine used to treat sudden (acute) attacks of hereditary angioedema (HAE) in adults and children aged 12 years of age and older. It is not known if EKTERLY is safe and effective in children under 12 years of age.

IMPORTANT SAFETY INFORMATION

Before taking EKTERLY, tell your healthcare provider about all of your medical conditions, including if you:

  • Are pregnant or planning to become pregnant. It is not known if EKTERLY can harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if EKTERLY passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while taking EKTERLY.
  • Have liver problems.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking EKTERLY with certain other medicines can cause side effects or affect how well EKTERLY or the other medicines work. Especially tell your healthcare provider if you take any of the following, as their use with EKTERLY is not recommended: itraconazole, phenytoin, efavirenz.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

What are the possible side effects of EKTERLY?

The most common side effects of EKTERLY include headache. For more information, ask your healthcare provider or pharmacist. Talk to your doctor for medical advice about side effects.

You are encouraged to report side effects related to KalVista products by calling 1-855-258-4782. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information, including Patient Information.